Motilium blocks peripheral and central dopamine receptors remove the inhibiting influence of dopamine on motor activity of the gastrointestinal tract and increases evacuative and tone of stomach. It has an anti-vomiting effect, soothes hiccup and nausea. Motilium is used to treat vomiting of different origin, hiccup, atonic gastrointestinal tract, the necessity to accelerate peristalsis for X-ray examination, dyspepsia caused by slow stomach, gastroesophageal reflux disease, esophagitis, gas, heartburn with or without passage of gastric contents into the mouth.
Dosage and directions
Make Motilium orally 30 minutes before a meal. In adults and children older than 5 y.o. take 10 mg 3-4 times a day when dyspepsia is diagnosed. In patients with severe nausea and vomiting, Motilium daily dose is 20 mg 3-4 times a day. In patients with kidney failure correction of the dose is necessary, a number of daily intakes should not exceed 1-2 times. This is only general recommendations and for each individual case consult your doctor as different conditions require different correction of the dose.
If you are pregnant or think you might be pregnant first consult your doctor or pharmacist before taking Motilium or any other medicine. Do not take Motilium if you are breast-feeding.
Hypersensitivity, bleeding in the gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, infancy (younger than 5 y. o. and ones whose weight is less than 20 kg). Caution should be experienced in patients with renal/hepatic insufficiency, during lactation, pregnancy.
Possible side effect
Among most common side effects these can occur transient spasms of the intestine, allergic reactions (skin rash, urticaria), hyperprolactinaemia (galactorrhoea, gynecomastia).
Cimetidine and sodium bicarbonate reduce effects of Domperidone. Anticholinergic medications neutralize the effect of Motilium. Blood levels of Motilium are increased by azole antifungal agents, macrolide antibiotics, HIV protease inhibitors, nefazodone (antidepressant). Motilium is compatible with antipsychotic (neuroleptics) medications, dopamine receptor agonists (bromocriptine, L-dopa). Simultaneous treatment with paracetamol and digoxin had no effect on the concentration of these medications in the blood.
If you missed a dose take it the soonest. If it is almost time of your next dose just skip it and return to your regular dosage schedule.
Symptoms of overdose may include drowsiness, disorientation, extrapyramidal disorder (especially in children). If you think that took too much of Motilium and experience symptoms listed above contact your doctor immediately, you may need medical help.
Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets.